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Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane

door Ksenia Guseva
Staat: Nieuw
€ 92,88
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Ksenia Guseva Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane
Ksenia Guseva - Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane

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Levering: tussen 2021-05-14 en 2021-05-18
Verkoop en verzending: Dodax EU

Omschrijving

With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.

Bijdragers

Schrijver:
Ksenia Guseva

Productdetails

Opmerking illustraties:
26 schwarz-weiße und 20 farbige Abbildungen
Remarks:
Nominated as an outstanding contribution by the University of Aberdeen


Contains essential new results on the statistical mechanics and dynamics of macromolecular assembly


Yields important conclusions and predictions for biological membranes


Work done in close cooperations with biologists studying membrane proteins
Mediatype:
Buch gebunden
Uitgever van videogames:
Springer Berlin
Taal:
Englisch
Aantal pagina’s:
80
Samenvatting:

Framed by a statistical physics perspective, this volume describes both the process of self-assembly and the impact of spatial organization on the function of membrane proteins. Using methods from equilibrium and non-equilibrium statistical mechanics, the text demonstrates the importance of the protein-protein interactions.


Basisgegevens

Product Type:
Hardback book
Afmetingen pakket:
0.234 x 0.155 x 0.01 m; 0.272 kg
GTIN:
09783642239878
DUIN:
N8TU8PA65VB
€ 92,88
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